The church has a chancel of the late 13thc. and the 15thc. In the nave there are arcades that date from the late 14thc. but set into the walls of the north and south aisles are scalloped capitals that came from a previous, 12thc. nave arcade. The west tower was added in 1853.

In 1207 William, Abbot of Bec, assigned the churches of Poulshot, Brixton Deverel, and Durrington to the Bishop of Salisbury in return for the prebend of Ogbourne and the churches of Ogbourne, Hungerford, and Wantage. The advowson of the church of Poulshot remained vested in the Bishops of Salisbury, who, as far as is known, never surrendered their right of presentation to the living.

The fragments, Pevsner observes, show the church had narrow aisles from an early date. This would suggest that the arcade was rebuilt, but unusually, the aisle not expanded in width.