Clifton Hampden was not mentioned by name in the Domesday Survey, but (following VCH) was certainly included with the Bishopric of Dorchester. In 1070 that see was moved to Lincoln, and Clifton went with it. The bishop, however, was obliged to enfeoff much of his land, including Clifton, to meet his feudal obligations, and the lordship of the manor was divided between to three of the bishops knights: The Le Moine fee was the main one and it was held by Robert Monachus from the Bishop in 1166 and apparently remained in the same family into the 14thc.
The chapel was a daughter to Dorchester Abbey, and and was part of its endowment when it was founded in 1140. It did not gain full parochial rights until the 19thc, although it was sometimes referred to aas a parish as early as the 16thc. Technically, however, it was a chapel-of-ease for the tenants of the manor as late as 1817.