The main Domesday holding in Middleton (Milton Keynes) was a manor of 8½ hides held by Godric Cratel from the king. This had been held by Queen Edith in 1066. The 30 listed people represent a total population of around 150, and the holding also included a mill and meadow for 8 ploughs. Smaller parcels were those of Hugh, who held half a hide from Walter Giffard, held by Oswig, a man of Aelfric, in 1066; and Otbert, who held a hide from William FitzAnsculf, held by Saeweald, a man of Wulfweard Cild in 1066.
In the 12thc the manor was held by the Bereville family, whose line ended in a daughter called Mabel who married Hugh de Kaynes around 1166. This family remained Lords of the manor until the early 14thc, although for a period between c.1170 and c.1230 a younger branch of the Bereville family are recorded as holding lands in the parish. The advowson of the church descended with the manor. It is first mentioned in 1221 when Luke de Kaynes presented Ralph de Kaynes to the rectory.