8 hides in Great Wymondley were held by the church of St Mary, Chatteris before the Conquest, but the manor was taken from that church by Earl Harold, c.1063 and attached to his own manor of Hitchin. A further 3¼ hides were held by Swen, a man of Harold, before the Conquest. In 1086, King William held the 8 hides and the smaller manor was held by Goisbert de Beauvais.
Before the end of the 11thc, the entire estate was given to Reginald de Argentein, and it remained in this line until the 15thc.
The church was originally a chapel to Hitchin. The Abbess of Elstow claimed, in 1199, that it had been granted, with Hitchin and its church, to her abbey, a claim opposed by Reginald de Argentein on the grounds that his ancestors had already presented to the church. Reginald’s son Richard acknowledged the right of the Abbess of Elstow to present to the church, which she appropriated around this time, and the church remained with Elstow until the Dissolution.