Heythrop, along with Kiddington 7 miles to the S, was given c. 780 by Offa, king of the Mercians, to Worcester Priory. It was reputedly lost by the priory in the 9thc, and in 1086 was held, as was Kiddington, by Hasculf Musard. Assessed at 5 hides and held as knight’s fee, the manor descended in the Musard family, but as with their other Oxfordshire estates, the connection became tenuous in the late 13thc.
There is no mention of a church at Edrope (Heythrop) in the Domesday book. The presence of a chaplain was recorded by the late 12thc, but the benefice is invariably referred to hereafter as a rectory. In the 13thc a church at Asterleigh, no longer in existence but united with Kiddington, was a dependency of Heythrop, bringing its parishioners there for burial and making payment. This association may have originated in the close tenurial connection between Heythrop and Kiddington from the 8thc. If so, it would indicate early building of the church at Heythrop (VCH).
In 1086 only twenty-three people were recorded at Heythrop, and this number was not equalled again until the 19thc. By the 14thc the village was reduced to a church, a manor house and a few cottages. Reasons for the depopulation might be natural causes or changes in land use, but not the Black Death. Even after Heythrop House was built by Thomas Archer in the early 18thc for Charles Talbot, Earl of Shrewsbury, the situation was unchanged as he and his heirs rarely lived there. In 1738 the incumbent complained how melancholy it was to be sent to St Nicholas to read to the church walls. After a fire gutted the inside of the house in 1831, it remained unoccupied until it was bought by Thomas Brassey, a railway magnate, in 1870. He renovated the house, built estate cottages, a school, and a larger church with a vicarage, claiming that the little church's capacity was outgrown.
Fortunately the church had been drawn by J.C. Buckler in 1822, but his drawings probably do not show the true extent of the neglect it had suffered. Buckler's main view from the SE shows a nave that was higher and wider than the chancel, but little larger. The distant S doorway is situated on a shallow projecting bay at the far W end, with castellation above. Its recessed orders are represented by a series of concentric lines broken by the capitals and imposts. A NW view shows clearly a N nave doorway of four orders, with plain jambs, a lintel and simple diapered tympanum. Two of the orders appear decorated. The relief panel of shepherds is mounted above it. The fate of this doorway is unknown, although the panel was reset.
The original building, referred to as 'Old St Nicholas', is now used as a mortuary chapel, serving the graveyard that is still in use. Both it and the 19thc church now belong to the benefice of Great Tew and Little Tew with Heythrop.