The medieval church was demolished and totally rebuilt by Alfred Waterhouse in 1876-7. Apart from some 15thc window tracery reused, all that survives are the partly recarved capitals of the late 12th arcades, and a 13thc Purbeck marble font, with a frieze of plain pointed arches. Images of the church show that it had a late-medieval exterior.

Twyford is recorded in the Domesday book as a valuable manor belonging to the bishop of Winchester, valued £20 in 1066 and £32 in 1086. A church is mentioned in the settlement in the entry. The church was appropriated to the hospital of St Cross by 1291, with a vicarage.

The waterleaf capitals place the arcades in the last quarter of the 12thc.