Archaeological evidence (roads, coins, and aerial photographs) suggest that there may have been a Roman settlement in the vicinity, S of the village across the valley (Neave 1977, 7-8; Faull 1974, 9-11, fig. 2). This may have been followed by Anglian settlement nearby.
DB says that in Everingham, with its berewicks Londesborough, Towthorpe and Goodmanham, there were 17 carucates; Archbishop Eldred had them and afterwards they were in the hands of Archbishop Thomas. Two clerks and one knight held the land in DB, and there is no mention of a church at any of the settlements. In the time of King Edward the manor had been worth £14, at the time of DB, £6. (VCH II, 211) The Archbishop had 7½ carucates at Londesborough. (VCH II, 319)
Herbert the Chamberlain was the brother-in-law of King Stephen and the father of William Fitzherbert, the archbishop who was canonised as St William of York. The inscribed stone at Weaverthorpe records that this Herbert built that church, and it is likely that he also built Londesborough church. (Neave 1977, 43)
Archbishop Thomas II gave Londesborough with Towthorpe, and Weaverthorpe with Helperthorpe, to Herbert the Chamberlain and Herbert Fitzherbert c.1109. The churches of these estates were granted to William Fitzherbert by his father and brother. (Neave 1977, 9, 11; Norton 2006, 49).