Great Bedwyn is a village on the River Dun about 13 miles W of Newbury. The church lies to the S of the village on the site formerly occupied by the Anglo-Saxon church. The building is a flint with limestone dressings structure erected from the 12thc consisting of a chancel (rebuilt in the late 13thc), an aisled nave (dating to the end of the 12thc), a S porch, a N vestry and a central tower. The clerestory was refenestrated in the 15thc, while the transepts and crossing date from the early 14thc. The W façade was built in 1843 and the church was heavily restored in 1853-5 by Thomas Henry Wyatt. Romanesque sculpture survives on the nave S and N arcades.

The Domesday Survey records that in 1066 and in 1086 'Beduinde' was held by Brictward the Priest, and a church is also mentioned. The revenues of the church were granted to Salisbury Cathedral in 1091 as part of a prebend along with St Michael, Little Bedwyn. The prebend of Bedwyn as a whole was valued at £50 in 1291.

The Buildings of England comments that the arcades capitals are "unfortunately atrociously over-restored".