Great Kimble was held by Hugh de Bolbec from Walter Giffard in 1086. It was assessed at 20 hides with meadow for 11 ploughs and wood for fences. Before the Conquest it was held by Sigeraed, a thegn of King Edward. Great Kimble church was part of the original endowment of Missenden Abbey, along with the churches of Great Missenden, Chalfont St. Peter and Weston Turville and its chapels within the county and other churches and lands in Huntingdonshire and Oxfordshire. Missenden Abbey was a house of Augustinian canons, founded in 1133 by one William of Missenden. Great Kimble church and manor were counted among the possessions of the abbey in Henry VIII’s Valor Ecclesiasticus, made prior to the Dissolution.
The parish is now in the benefice of Ellesborough, the Kimbles and Stoke Mandeville.