Combe was assessed in Hurstbourne hundred (later called Pastrow hundred), Hampshire in the Domesday Survey. It was held by Ernulf de Hesdin in 1086, and before the Conquest by Eadric. It was assessed at 3 hides before the Conquest and 2 afterwards, and there was a church there and a total of 28 recorded inhabitants, probably representing a population of approximately 120.
After Ernulf's death his widow granted the manor to the abbey of Bec Hellouin in Normandy, and towards the end of the 12thc it was attached to the convent of monks from Bec established at Ogbourne, Wilts. Combe remained in the hands of the Prior and Convent of Ogbourne until the reign of Henry IV.
Combe remained in Hampshire (and in Winchester diocese) until 1895, when the boundary changes shifted it into Berkshire.