Rame is a hamlet of the civil parish of Marker-with-Rame about a mile SW of Cawsand, on the Rame Peninsula in SW Cornwall. The present church was consecrated in 1259, and probably replaced an earlier building. The structure was built in slatestone rubble with granite dressings, and the elements belonging to the 13thc consist of the chancel, the nave, the N transept, the spire and the upper part of the tower. By 1321 the tower arch and the S transept were completed. In the 15thc the rest of the structure was built, and the S aisle replaced the S transept. The N porch, the vestry and the N transept were built in the 19thc. The church was restored in 1845 and again in 1885. A 12thc tympanum has been reset on the W wall of the S aisle.

During the reign of King Edgar Rame was granted to Tavistock Abbey by Earl Ordulf of Mercia, son-in-law of the founder of the abbey; the Domesday Survey confirms this grant in 1066. The survey also records that in 1086 Rame was held by Ermenhald of Antony, and valued £2. The first record of the church dates to 1259, when Walter de Bronescombe, Bishop of Exeter, consecrated the building on 15 October; a second ceremony was held in 1321 for the consecration of the transept.

Edmund Harold Sedding (1909, 345), says that 'the tympanum is of unusual design and of early Norman workmanship'. The decorative motif of the central medallion of the tympanum resembles the decoration of the tympanum at Mylor (Cornwall). Easton (2015), 46, suggests that the central circle decorating the tympanum encloses the reverse design of a consecration cross.