Sotwell was held by Hugh of Port from the Abbot of Winchester before 1066, the abbey holding it in lordship for the supplies of the monks. The chapel is first mentioned in 1158 as a dependency of the church of St Lucian, Wallingford (which belonged to the Priory of St Frideswide, Oxford). St Lucian's disappeared after Wallingford was decimated by the plague of 1348, and the chapelry passed to St Leonard's, Wallingford. In 1868 it was separated from St Leonard's and attached to Brightwell, and in 1948 Brightwell and Sotwell were united as a civil parish.