Marlston does not appear in the Domesday Survey, but it is identified by VCH as a manor of 4 hides in Bucklebury held by the Count of Evreux in 1086. William, Count of Evreux founded a monastery in Noyon in Normandy, and endowed it with his holdings in England, and his grandson Simon confirmed this gift in the mid-12thc. It remained a possession of Noyon until the reign of Henry V when it was given to his priory of Sheen in Richmond.
The chapel was built by Geoffrey Martel, a 12thc Lord of the Manor of Bucklebury as a chapel of ease to the parish church. It passed to Reading Abbey with Bucklebury church, and was assigned to the Hospital of St John.