The small stone church at Adwell, near Lewknor in SE Oxfordshire, comprises nave, chancel, transeptal chapels and a slender bell-cote at the W end. The original church, built in the late 12thc., had been a two-cell structure, probably enlarged in the 13thc. By the mid-19thc. it was beyond repair and was rebuilt in 19thc. Gothic style by A.W. Blomfield in 1865. The S doorway, reset from the earlier church, is the only Romanesque survival.

Before the Conquest Adwell was held by the Saxon Wulfstan, probably the same man that held neighbouring Aston (Rowant) and Britwell Salome. By 1086 the manor had passed into the hands of Miles Crispin and so became part of the honor of Wallingford. Miles' tenant at Adwell, William de Sulham, gave tithes to Abingdon Abbey in 1104.

Adwell is in the benefice of Thame with Crowell, Lewknor and Sydenham.