Letcombe Regis is a village less than 2 miles SW of Wantage on the edge of Lambourn Downs. The church is a large building on a high mound in the centre of the village. It consists of a nave, chancel and W tower, all post 12thc. Only the font is 12thc.

In 1066 was held by King Edward, and in 1086 by King William in demesne. It was rated at 3 hides and also contained 5 mills and 225 acres of meadow. There was a church held by the priory of Benedictine nuns at Amesbury, along with 1 virgate of land. In 1136 King Stephen granted the manor to Cluny Abbey, but in 1204 it was taken back into the King (John's) hands and granted to Chertsey Abbey in the following year, but it was back with Cluny by 1209.