West Challow is a village at the foot of the Berkshire Downs, in the Vale of White Horse district of the county, 2 miles W of Wantage. The village is on Childrey Brook, a tributary of the River Ock. The church is on the S edge of the village centre, and has a 12thc nave and a 15thc chancel and porch and the windows in the east, north and south walls are original. The church was reseated and repaired in 1891, according to a notice in the porch. Romanesque work is found on the N doorway and the font.

The manor was granted before 1086 to the nuns' priory of Amesbury, and remained in the nuns' possession until the priory was dissolved in 1541.

The crudely carved and unusual forms of the N doorway capitals are of little help in dating, but the monolithic capitals and imposts and the impost profile suggest a date towards the end of 12thc. Pevsner doubts that the rim decoration of the font can be Norman, but it is no odder than the capitals and probably by the same workshop.